出生在佛罗伦萨，他开始在工作的安德烈·韦罗基奥的作坊。他的主人去世后，他继承了车间的方向。对于皮斯托亚大教堂他完成的画施洗约翰和圣图斯之间麦当娜登基它已经被他的主人，韦罗基奥已部分上色，但被未完成时，韦罗基奥去威尼斯。

当中他的其他早期作品的报喜在乌菲齐，一个麦当娜与儿童在萨包达美术馆的都灵，和儿童崇拜中的奎里尼斯坦帕利亚威尼斯。一个后期是麦当娜和圣徒（卢浮宫）（1493）和儿童崇拜的乌菲齐。在菲耶索莱，他重拍的部分安吉利科在教堂的祭坛的面板圣多米尼克。

罗伦佐的成熟的作品（如受难在哥廷根市博物馆，在牧羊人的崇拜中的乌菲齐的报喜在剑桥和麦当娜和圣徒的皮斯托亚）通过影响弗拉·巴尔托洛梅奥，佩鲁吉诺和年轻的拉斐尔。

最近一个时期，迪克雷迪的作品之一，获得了关注，当学者指出脸之间的相似蒙娜丽莎由达芬奇和面对卡特琳娜·斯福尔扎由他的肖像。卡特琳娜·斯福尔扎是的夫人弗利和伊莫拉在罗马涅大区，后来的囚犯切萨雷波吉。画像，也被称为香格里拉DAMA代gelsomini，现已在弗利的Pinacoteca。
 

Born in Florence, he began working at Andre Verrocchio's workshop. After his master's death, he inherited the direction of the workshop. For Madonna between Pistoia Cathedral he completed the painting of John the Baptist and Shengtusi reign it was his master, Vee Lo Keogh has been part of the color, but was not completed, Vee Lo Keogh went to Venice.
Among his other early works of the Annunciation in the Uffizi, a Madonna and the children of the museum in Turin package SA, and children in worship Krishna in nice Tampa Leah Venice. A late Madonna and Saints (Le Louvre Museum) (1493) and children's worship of the uffizi. In Fiesole, Angelico for his part in a remake of the altar of the Church of Saint Dominic panel.
Lorenzo's mature works (such as the passion of the museum in Gottingen City, in the adoration of the shepherds in the Uffizi of the Annunciation in Cambridge and Madonna and Pistoia saints) by Fra Bartolomeo, Perugino and Rafael young.
A recent period, one of two grams of Da Vinci's works, gained the attention when scholars pointed out the resemblance between the faces of Monalisa by the face of the portrait of the face by Mr Katerina Sforza. Katerina Sforza is the wife of Foley and Imola in Rome, Auvergne later, the prisoner Cesare Poggi. The portrait, also known as the Shangri-La DAMA gelsomini, is now in Foley Pinacoteca.